Here we analyse the evolutionary relationship between Jumonji C (JmjC)- domain-containing proteins and discuss their cellular functions in relation to their . Proteins containing JmjC domain are predicted to be metalloenzymes that adopt The JmjC has been shown to function in a histone demethylation mechanism. The demethylase activity of the JmjC domain-containing proteins is Purification and identification of a histone demethylase activity.a, Histone.

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UCSC genome browser More A summary of the content will be automatically included. Polycomb complexes repress developmental regulators in murine embryonic stem cells Laurie A.

Histone demethylation by a family of JmjC domain-containing proteins.

Has a role in regulating lifespan. Systems used to automatically annotate proteins with high accuracy:.

No experimental confirmation available. National Institutes of Health. The N-termini “tails” of the histone proteins are subject to a diverse array of posttranslational modifications including methylation.

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By posting Material you grant to F an irrevocable non-exclusive royalty-free license to keep a copy of Material for a reasonable period and as necessary to enable it to comply with its legal obligations. Bgee i WBGene Expressed in 5 organ shighest expression level in multi-cellular organism. Histone demethylation by a family of JmjC domain-containing proteins.


Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein demethylation mechanism that is conserved from yeast to human.

Expanding role of the jumonji C domain as an RNA hydroxylase. Institutional access Recommend FPrime to your librarian or information manager to request an extended free trial for all users at your institution. The sequence of this isoform differs from proteinw canonical sequence as follows: Dissecting the biological roles of Kdm 3 b and Kdm 3 a lysine demethylases Ioannis Kasioulis The information stored in this subsection is used to automatically construct alternative protein sequence s for display.

I am a Faculty Member who recommended this article. Whereas most covalent histone modifications are reversible, until recently it was unknown whether methyl groups could be actively removed from histones. ProtoNet; Automatic hierarchical classification of proteins More Comparative Toxicogenomics Database More By clicking “I accept the Terms and Conditions relating to Materials” before you submit your first Material as hereinafter defined you agree to be bound by these conditions every time you submit Material.

See the description of this molecule in ChEBI. Using a biochemical assay coupled with chromatography, we have purified a novel JmjC domain-containing protein, JHDM1 JmjC domain-containing histone demethylase 1that specifically demethylates histone H3 at lysine 36 H3-K JmjC domain-containing histone deme You work at the same institute as any of the authors.

Jumonji C domain-containing proteins were first identified with a role in the modulation of histone methylation marks. jmjc-domain-contaniing


This isoform has been chosen as the ‘canonical’ sequence. Recommendations Abstract Comments You have reached your article limit. See the description of this reaction in Rhea.

Show all Align All Isoform a identifier: Select the link destinations: Q95Q98 Primary citable accession number: TranscriptionTranscription regulation. Differential intron retention in Jumonji chromatin modifier demethylatioon is implicated in reptile temperature-dependent sex determination Ira W. User comments must be in English, comprehensible and relevant to the article under discussion.

Schofield Journal of inorganic biochemistry This Agreement shall begin on the date hereof.

This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and jmjc-domaih-containing at the single-cell level. N 6N 6 -dimethyl- L -lysine residue.

JmjC-domain-containing proteins and histone demethylation – Semantic Scholar

Material does not reflect the views or opinions of F, its agents or affiliates. Additionally, this section gives relevant information on each alternative protein isoform. Unlike many of the other histone modifications which are transient, methylation was thought to be permanent, until the relatively recent identification of the first demethylases.

Encyclopedia of Proteome Dynamics More Reactome – a knowledgebase of biological pathways and processes More This paper has highly influenced 45 other papers.